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Phage41Health - The Phage Therapy Consortium
856764 Oberschleissheim
Professor Otto Hupp Str. 15
Deutschland
Represented by:
Dr. Joachim J. Bugert
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CV Dr Bugert
*13.12.1963
Current position: Bundeswehr Institute of Microbiology (IMB), Phage laboratory
Deputy Director IMB, Laboratory Group Leader and Chief of Virology
Neuherbergstr. 1, 80937 München; Tel: +49 89 9926923277
Email: [email protected]
Curriculum vitae
1985 – 1991 Medical studies - Ruprechts-Karl University of Heidelberg (RKU HD), Germany.
1987 – 1994 Doctoral dissertation in Exp. Virologie - RKU HD, Germany.
1992 – 1993 Junior House Officer in Gastroenterology/ Inf. Diseases - RKU HD, Germany.
1994 – 1996 Post-Doctoral Fellow - NIH, NIAID, LVD (B. Moss), Bethesda, MD, U.S.A..
1996 – 2003 Registrar in Virology - University Hospital, Heidelberg (UHD), Germany.
1999 – 2016 Reserve Medical Officer - incl. Bernard Nocht Institute, Hamburg, Germany.
1999 – Consultant Microbiologist/Virologist - training for registration, UHD. Registered 2006.
2001 – Lecturer (ext.) - Faculty of Medicine, RKU HD, Germany.
2003 – 2016 Senior Lecturer (Assoc. Professor) - Dept. of Med. Microbiology, Cardiff University, Wales, UK.
2007 – Subject Editor - (human viruses), from 5/2011 co-Editor-in-Chief VIRUS GENES.
2016 – Surgeon CDR (JMS-Navy), from 2020 Deputy Director, Bundeswehr Institute of Microbiology.
Phage Research
1985 – 1994 Use of M13 & Lambda phages in doctoral dissertation 'Molecular genetics of poxviruses'.
2003 – 2016 Collaboration with T. Walsh and M. Toleman: bacteriophage specific for multiresistant gram negative E coli (NDM - type carbapenemase resistance). ESCMID presentation and EID paper on NDM gram negative prevalence in Bangladesh.
2016 – Isolation & characterization of bacteriophage targetting 3/4MRGN Klebsiella pneumoniae (Kp). In vitro packaging with Kilian Vogele (TUM- INVITRIS spin-off). Phage therapy research with J. Hammerl (BfR), C. Willy (BwKrhs Berlin), S. Kiljunen (U Helsinki, Finland), M. Clokie - A. Millard, UL-UK, and colleagues at WRAIR (B. Swiercziewski), U.S.A. Papers on MRGN 4 Kp in Tunisia and specific TUN1 podophage (1), phage pipeline for compassionate use protocols (2), in vitro packaging of Kp phage (3), nanoluc recombinant Kp reporterphage based on TUN1 (4), Kp specific jumbophage (5), further work on Kp host range extended podophage (Appleman procedure) in progress.
2017 – Phage group at IMB with BSc, MSc, and doctoral students (cadet physicians J. Stender/ N. Jakob) - IMB technical support.
Phage network and funding
2017 – IMB Phage group funded by German Foreign Ministry Biosecurity mission to Tunisia, Biodefense program at IMB), and Deutsches Zentrum für Infektionsforschung (DZIF; DZIF - MD stipend).
2018 – Phage editorship established at VIRUS GENES - first phage editor: Andy Millard.
2019 – Phage therapy network (https://phage4-1health.org/; consortium journal VIRUS GENES) established with C. Willy, J. Hammerl, K. Vogele, A. Millard, S. Kiljunen and S. Würstle.
2021 – Membership of NATO STO RTG-HFM 313 (2019-2024)- 'Phage therapy in military medicine' - Chairs J.-P. Pirnay and C. Willy.
2022 – Phage research funding applications to JPI-AMR, SPRIND, and European Defense Fund.
Phage publications - 5 recent (JJB Citations: 1598, h-index 21. https://orcid.org/0000-0002-0556-3211)
- Eckstein S, Stender J, Mzoughi S, Vogele K, Kühn J, Friese D, Bugert C, Handrick S, Ferjani M, Wölfel R, Millard A, Ben Moussa M, and Bugert JJ. Isolation and characterization of lytic phage TUN1 specific for Klebsiella pneumoniae K64 clinical isolates from Tunisia. BMC Microbiol. 2021 Jun 21;21(1):186. doi: 10.1186/s12866-021-02251-w. PMID: 34154528; PMCID: PMC8215767.
- Practical Assessment of an Interdisciplinary Bacteriophage Delivery Pipeline for Personalized Therapy of Gram-Negative Bacterial Infections. S.Würstle, J. Stender, J.- A. Hammerl, K. Vogele, K. Rothe, C. Willy, and J.J. Bugert. MDPI Pharmaceuticals. 2022. Accepted.
- Emslander Q, Vogele K, Braun P, Stender J, Joppich M, Abele M, Meng C, Ludwig C , Bugert JJ, Willy C, Simmel FC, and Westmeyer G. Personalized Production, Non-Genomic Engineering, and Time-Resolved Proteomics of Therapeutic Phages for Biohazardous and Multidrug-Resistant Bacteria. Preprint: http://dx.doi.org/10.2139/ssrn.3887804
- Expression of nanoluciferase in a podovirus based reporterphage and use for high sensitivity detection Klebsiella pneumoniae in clonical material. Hollenbeck J, Bugert JJ and Eckstein S. VIRUS GENES submitted.
- Potential of giant phage muc347 for the treatment of infections with multidrug- resistant Klebsiella pneumoniae. Stender J, Friese D, Vogele K, Kiljunen S, Bugert JJ, and Hammerl J. Gesellschaft für Virologie Abstrakt 242 - München 30.3.-2.4.2022. Manuscript in preparation.